Txoj kev txhim kho ntawm tooj liab peptides

GHK yog Tripeptide thawj cais los ntawm tib neeg ntshav los ntawm Pickart li al. Xyoo 1973. Nws tau pom nyob rau hauv kev kawm txog cov tshuaj yeeb dej uas muaj cov nyhuv tib yam rau kev laus thiab cov nqaij mos. Kev tshawb fawb tom ntej tau qhia tias cov kab ke ntawm no Truckeptide yog gly} l {}}} l} l} l} L ions, ua kom ghk cu complexes. Kev tshawb fawb tau pom tias GHK ua haujlwm nyob rau hauv daim ntawv ntawm cov nyom nrog tooj nkab ions.
Pickart li al. tau pom tias ghk cu accelitates cov qhov ntswg kho kom zoo thiab muaj kev cuam tshuam, txhim kho lub cev kom tau txais cov tawv nqaij hloov ntshav, thiab muaj anti- pob khoom. Cov kab mob ntawm cov kab txhab zais cia cov neeg tiv thaiv kev tiv thaiv kom tawg ohk thiab lwm yam kev kho mob cytokines txhawb. GHK nws tus kheej yog ib feem ntawm ib pawg loj ntawm cov roj sib xyaw me me peptide tsim tawm thaum lub sij hawm protein tawg. Thaum tooj liab ions tau ntxiv rau cov peptide me me, peb pom tias cov kev sib xyaw me me muaj kev txhim kho zoo, thiab cov peptides no yuav tsis yog decomposed, qhia tsis zoo rau cov enzymes.
Tus yam ntxwv loj tshaj plaws ntawm GHK yog qhov tsim ntawm cov nyom nrog CU Iions, uas tseem ceeb heev vim tias muaj ntau cov enzymes tseem ceeb hauv tib neeg lub cev thiab daim tawv nqaij uas xav tau CU IAS. Cov enzymes no ua lub luag haujlwm hauv kev sib txuas cov nqaij mos, tshuaj tiv thaiv kab mob tshuaj tiv thaiv kab mob, thiab kev ua pa cellular. CU IT tseem ntaus lub luag haujlwm thiab tuaj yeem cuam tshuam cov cwj pwm ntawm tes thiab cov metabolism hauv xov tooj. Piv txwv li, tus nqi txaus yog lub teeb liab rau cov qia cell kev sib tw thiab cov nqaij kho. GHK kuj pab kom txo cov kev xav ntawm lub xeev dawb CU Ions thiab tiv thaiv oxidative kev puas tsuaj
Kev tshawb fawb tom ntej los ntawm Borel thiab Maquart thiab pom tias zoo nkauj ntawm collagen thiab glycosaminoglycans ntawm cov khoom siv qis heev (1-10 nanomolar).
Xyoo 2001, McCormacack li al. pom tau tias fibroblasts nrog DNA hauv cov neeg mob tuaj yeem rov qab ua lawv cov peev xwm rov ua dua tshiab tom qab tau txais hluav taws xob ntau dua thiab cov tshuaj kho mob. Ghk kuj tseem tuaj yeem nyiam cov tshuaj tiv thaiv kab mob thiab cov hlwb endothelial rau kev tsiv teb tsaws chaw ntawm lub qhov chaw raug mob.
Lub peev xwm ntawm GHK CU los txhawb kom lub qhov txhab zoo tau ua qauv tau los ntawm ntau cov kev sim tsiaj. Hauv kev sim luav, GHK CU tuaj yeem kho cov qhov ntswg kho kom zoo thiab txhawb kev ua kom loj hlob ntawm angiogenesis, nce qib ntawm antioxidant enzymes hauv cov ntshav. Cov molecule no tseem ua rau mob cov qhov txhab txias hauv nas, nas, thiab npua. Nyob rau hauv cov ischemic mob ntshav qab zib nas, nws tuaj yeem txhawb kho kho kom zoo, txo tnf alpha qib thiab txhawb collagen synthesis. Nws kuj tseem tuaj yeem txhawb txoj kev kho ko taw ko taw hauv ncoo kub. Cov ntaub ntawv no ntawm daim tawv nqaij dua tshiab tau nthuav tawm cov ntawv thov ntawm GHK hauv kev ua lag luam zoo nkauj.
Nyob rau hauv xyoo tas los, GHK CU tau tshaj tawm tias yog kev kho mob ntawm cov kab mob ntsws, tawv nqaij, thiab lwm yam kab mob. Raws li cov ntaub ntawv, nws tuaj yeem txhawb lossis downregulate ze li 4000 tib neeg cov noob, thiab nws tuaj yeem kho cov DNA rau lub xeev muaj kev noj qab haus huv. Cov kev tshawb fawb no muab cov tswv yim tshiab rau kev hloov kho daim tawv nqaij.
Nyob rau hauv physiological cov kev mob, Ghk Cu complexes tuaj yeem tsim thaj chaw ntawm CU los ntawm cov cheeb tsam thiab tib neeg lub ntsej muag. Lawv kuj pom tias CU IAS tuaj yeem muab tau yooj yim thiab khi rau tus tooj liab thauj cov chaw ntawm tib neeg albumin. Nws tau raug pov thawj tias Redox cov yam ntxwv ntawm CU ions khi rau GHE Truneptides yog ntsiag to, ua CU ETS nkag rau hauv lub cell muaj kev nyab xeeb rau lub cell.
Qhov kom zoo dua ntawm CHK CU tshaj Chk yog tias muaj ntau cov enzymes tseem ceeb hauv tib neeg lub luag haujlwm, uas yog kev tiv thaiv kab mob antiOxidant, thiab kev ua pa ntawm cellular. CU IT tseem ntaus lub luag haujlwm thiab tuaj yeem cuam tshuam cov cwj pwm ntawm tes thiab cov metabolism hauv xov tooj. Piv txwv li, tus nqi txaus yog lub teeb liab rau cov qia cell kev sib tw thiab cov nqaij kho. GHK kuj pab kom txo cov kev xav ntawm lub xeev dawb CU Ions thiab tiv thaiv oxidative kev puas tsuaj.